Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions
Linara R. Yakupova, А. А. Скуредина, Pavel O. Markov, Irina M. Le‐Deygen, Еlena V. Kudryashova
Abstract
Here we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures of obtained polyesters and polyurethanes nanoparticles (120–200 nm) were investigated by NMR and FTIR-spectroscopy. The PXRD pattern demonstrated that HPCD polymers form complexes with meropenem (MP), and the majority of MP molecules are encapsulated into a complex. MP’s imprinting in the HPCD-HMD polymer matrix lead to an encapsulation efficiency of up to 82%. HPCD-HMD and HPCD-SA polymers increase MP’s stability during the storage of its aqueous solution (in 1.4 and 1.2 times, respectively). In contrast, HPCD-CA polymer negatively affects MP’s stability. In prospect, the HPCD-HMD polymer may be promising for the development of a highly efficient drug delivery system for MP.