Rapid emergence of recalcitrant dermatophytosis caused by a cluster of multidrug-resistant <i>Trichophyton indotineae</i> in China
Wenting Xie, Xue Kong, Hailin Zheng, Huan Mei, Naicen Ge, Suquan Hu, Qiong Wang, Yuying Huang, Xiaodong She, Weida Liu, Guanzhao Liang, Xiaofang Li
Abstract
We describe 14 cases of native refractory dermatophytes caused by Trichophyton indotineae diagnosed at a hospital in China since 2021, primarily diagnosed in the past 1 year and from the same province. Trichophyton indotineae isolates were resistant to multiple antifungals and harboured Phe397Leu or Leu393Ser substitutions in the squalene epoxidase enzyme. Short-term rapid emergence of multidrug-resistant T. indotineae in China poses increasing threats to public safety and warrants continued public health surveillance.
Topics & Concepts
TrichophytonMultiple drug resistanceChinaMedicinePublic healthMicrobiologyDermatologyBiologyAntifungalDrug resistanceGeographyPathologyArchaeologyNail Diseases and TreatmentsFungal Infections and StudiesInfectious Diseases and Mycology