Halogen-bonding-mediated synthesis of amides and peptides
Mingqin Huang, Junjie Li, Chi Zhang
Abstract
We report the first methods for halogen-bonding-mediated formation of amide and peptide bonds. The methods can be used to synthesize not only amides but also dipeptides, tripeptides and pentapeptides in good to excellent yields without racemization.
Topics & Concepts
TripeptideRacemizationChemistryHalogenPeptide bondAmideDipeptideHalogen bondCombinatorial chemistryPeptideOrganic chemistryStereochemistryAlkylBiochemistryChemical Synthesis and AnalysisFluorine in Organic ChemistrySynthesis and Catalytic Reactions