Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in bipolar disorder: a 2-sample bidirectional mendelian randomization study
Min Zhang, Xinwei Li, Lin Dong, Mengdi Jin, Mengtong Xie, Ningning Jia, Yane Liu, Fengyu Xue, Weizhen Li, Yuqing Yang, Haideng Song, Qingxing Lu, Lintong Jiang, Qiong Yu
Abstract
< 0.05), but no causal relationship between omega-6 levels and BD risk was unearthed. Our MR findings suggest that the ratio of omega-3, omega-6:omega-3 is associated with the risk of BD. It is important to be concerned about the risk of BD in individuals with low serum omega-3 intake and a high omega-6:omega-3 ratio.
Topics & Concepts
Mendelian randomizationOmegaPolyunsaturated fatty acidBipolar disorderSample (material)GeneticsPsychologyBiologyChemistryGenePsychiatryPhysicsCognitionFatty acidBiochemistryChromatographyGenotypeQuantum mechanicsGenetic variantsDigestive system and related healthDiet and metabolism studiesBirth, Development, and Health