Vemurafenib provides a rapid and robust clinical response in pediatric Langerhans cell histiocytosis with the BRAF V600E mutation but does not eliminate low-level minimal residual disease per ddPCR using cell-free circulating DNA
D. A. Evseev, И. И. Калинина, Е. V. Raykina, D. S. Osipova, З. А. Абашидзе, Anna Ignatova, А. М. Митрофанова, Alexey Maschan, G. А. Novichkova, Michael Maschan
Topics & Concepts
VemurafenibMedicineLangerhans cell histiocytosisV600EInternal medicineGastroenterologyOncologyMutationDiseaseCancerBiologyGeneMetastatic melanomaBiochemistryHistiocytic Disorders and TreatmentsSkin Diseases and DiabetesOcular Diseases and Behçet’s Syndrome