The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia
Jessica Brown, Luisa Iacovelli, Gabriele Di Cicco, Ben Grayson, Lauren Rimmer, Jennifer Fletcher, Joanna C. Neill, Mark J. Wall, Richard Teke Ngomba, Michael Harte
Topics & Concepts
NeuropathologySchizophrenia (object-oriented programming)NeurosciencePhencyclidineProtein kinase BAllosteric regulationPsychologyMAPK/ERK pathwayAllosteric modulatorCognitionPharmacologyReceptorMedicinePsychiatryInternal medicineSignal transductionNMDA receptorBiologyBiochemistryDiseaseNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingIon channel regulation and function