Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes
Jiayuan Xu, Guangying Xie, Wei-liang Yang, Wantao Wang, Zhuan Zuo, Wenbo Wang
Abstract
on NP cells, which were abrogated by upregulating Keap1 and silencing Nrf2. Taken together, we concluded that PRP secreted exosomal miR-141-3p to activate the Keap1-Nrf2 pathway, which helped to slow down IVD degeneration.
Topics & Concepts
MicrovesiclesKEAP1Cell biologyApoptosisChemistryIntervertebral discPlatelet-rich plasmaOxidative stressExosomeProgrammed cell deathCytoplasmGene silencingmicroRNACancer researchBiologyImmunologyBiochemistryPlateletAnatomyTranscription factorGeneSpine and Intervertebral Disc PathologyTendon Structure and TreatmentSpinal Cord Injury Research