A polyphenotypic malignant paediatric brain tumour presenting a <i>MN1‐PATZ1</i> fusion, no epigenetic similarities with CNS High‐Grade Neuroepithelial Tumour with <i>MN1</i> Alteration (CNS HGNET‐MN1) and related to <i>PATZ1</i>‐fused sarcomas
Fanny Burel‐Vandenbos, Gaëlle Pierron, Christian Thomas, Stéphanie Reynaud, V. Grégoire, Gwenaëlle Duhil de Bénazé, Sylviane Croze, N. Chivoret, Mrinalini Honavar, Dominique Figarella‐Branger, Claude‐Alain Maurage, Florence Pédeutour, Martin Hasselblatt, Catherine Godfraind
Abstract
The authors declare no conflict of interest. Figure S1. Sashimi plots illustrating splicing junctions for MN1 gene (a) and PATZ1 gene (b) respectively in EWSR1-PATZ1 sarcomas, in the current tumour and in control MN1 gene (a) or PATZ1 gene (b). Figure S2. Hierarchical clustering showing the reported tumour (yellow line) clustering tightly together within PATZ1-rearranged tumours (EP), and apart from the others tumour entities: ossifying fibromyxoid tumours (OF), extraskeletal myxoid chondrosarcoma (EMC) and the extraskeletal mesenchymal chondrosarcoma (EMC) (a) Figure S3. Unsupervised t-SNE analysis including 2801 samples comprising 82 distinct molecular CNS tumour entities showing that the tumour sample did not group with any known molecular entity. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.