The convergent total synthesis and antibacterial profile of the natural product streptothricin F
Matthew G. Dowgiallo, Brandon C. Miller, Mintesinot Kassu, Kenneth P. Smith, Andrew D. Fetigan, Jason J. Guo, James E. Kirby, Roman Manetsch
Abstract
-diamine installation, diastereoselective azidation of a lactam enolate, and a mercury(ii) chloride-mediated desulfurization-guanidination. The development of this chemistry enables the synthesis and structure-activity studies of streptothricin F analogs.
Topics & Concepts
Total synthesisNatural productYield (engineering)Sequence (biology)Product (mathematics)Convergent synthesisChemistryStereochemistryMathematicsBiochemistryMaterials scienceMetallurgyGeometryPhytochemical compounds biological activitiesPhytochemistry and Bioactivity StudiesTraditional and Medicinal Uses of Annonaceae