Cystamine reduces vascular stiffness in Western diet-fed female mice
Francisco I. Ramirez‐Perez, Francisco J. Cabral-Amador, Adam Whaley‐Connell, Annayya R. Aroor, Mariana Morales‐Quinones, Makenzie L. Woodford, Thaysa Ghiarone, Larissa Ferreira‐Santos, Thomas J. Jurrissen, Camila Manrique‐Acevedo, Guanghong Jia, Vincent G. DeMarco, Jaume Padilla, Luis A. Martinez‐Lemus, Guido Lastra
Abstract
This study evaluates the novel role of transglutaminase 2 (TG2) inhibition to directly treat vascular stiffness. Our data demonstrate that cystamine, a nonspecific TG2 inhibitor, improves vascular stiffness induced by a diet rich in fat, fructose, and salt. This research suggests that TG2 inhibition might bear therapeutic potential to reduce the disproportionate burden of cardiovascular disease in females in conditions of chronic overnutrition.