HSA-Lys-161 covalent bound fluorescent dye for <i>in vivo</i> blood drug dynamic imaging and tumor mapping
Yongkang Yue, Tingting Zhao, Yuting Wang, Kaiqing Ma, Xingkang Wu, Fangjun Huo, Fangqin Cheng, Caixia Yin
Abstract
blood drug concentration monitoring in mice, utilizing ibuprofen as a model drug. The non-invasive method avoided continuous blood sample collection, which fundamentally causes suffering and consumption of experimental animals in the study of pharmacokinetics. At the same time, the coupled fluorescent probe can be efficiently enriched in tumors in mice which could map a tumor with a high-contrast red fluorescence signal and could hold great potential in clinical tumor marking and surgical resection.
Topics & Concepts
FluorescenceCovalent bondChemistryIn vivoCoumarinDrugLysineBiophysicsCombinatorial chemistryBiochemistryOrganic chemistryPharmacologyBiologyAmino acidQuantum mechanicsBiotechnologyPhysicsProtein Interaction Studies and Fluorescence AnalysisMonoclonal and Polyclonal Antibodies ResearchAdvanced Fluorescence Microscopy Techniques