Access to thiazoles <i>via</i> [3 + 2] cycloaddition of 1,2,3-thiadiazoles with isonitriles
Qiaoyu An, Lei Liu, Zongyuan Tang, Han Luo, Li You, Mingchuan Xu, Baosheng Li
Abstract
The formal [3 + 2] cycloaddition of 1,2,3-thiadiazoles with isonitriles is developed to access structurally diverse 4,5-disubstituted thiazoles, in which the thioketene as a sulfo-2C-synthon is first disclosed.
Topics & Concepts
ThiadiazolesSynthonChemistryCycloadditionCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisCyclopropane Reaction MechanismsClick Chemistry and ApplicationsSynthesis and Catalytic Reactions