Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3
Wei Wen, Xiangmin Li, Mengge Yin, Haoyuan Wang, Liuxin Qin, Hui Li, Wenqiang Liu, Zekai Zhao, Qiongqiong Zhao, Huanchun Chen, Junjie Hu, Ping Qian
Abstract
; Co-IP: co-immunoprecipitation; hpi: h post-infection; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MOI: multiplicity of infection; PB1: N-terminal Phox/Bem1p; Rap.: rapamycin; Seneca Valley virus: SVV; SQSTM1/p62: sequestosome 1; SQSTM1-N355: residues 1 to 355 of SQSTM1; SQSTM1-C355: residues 355 to 478 of SQSTM1; SQSTM1-N392: residues 1 to 392 of SQSTM1; SQSTM1-C392: residues 392 to 478 of SQSTM1; SQSTM1-N388: residues 1 to 388 of SQSTM1; SQSTM1-N397: residues 1 to 397 of SQSTM1; UBA: ubiquitin association; Ubi: ubiquitin.
Topics & Concepts
BiologyAutophagyVirologyViral replicationReplication (statistics)VirusCell biologyGeneticsApoptosisMosquito-borne diseases and controlPlant and Fungal Interactions ResearchAnimal Disease Management and Epidemiology