Schiff base complexes, cancer cell lines, and anticancer evaluation: a review
Sheikh Abdul Majid, Jan Mohammad Mir, Gowhar Jan, Aabid H. Shalla
Abstract
This review examines the importance of Schiff base ligands and their metal complexes against cancer. The chemotherapeutic action of certain metal complexes especially cisplatin are currently used for treatment of cancer. The main limitation of such cancer related drugs is high toxicity and side effects. The development of new anticancer agents against several cell lines is described in this article. Based on reports from the last decade, we are still awaiting an efficient anticancer candidate.
Topics & Concepts
ChemistryCisplatinCancerSchiff baseCancer cellToxicityCancer cell linesCancer researchCombinatorial chemistryPharmacologyNanotechnologyStereochemistryChemotherapyInternal medicineOrganic chemistryMedicineMaterials scienceMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsFerrocene Chemistry and Applications