Electrochemical collective synthesis of labeled pyrroloindoline alkaloids with Freon-type methanes as functional C1 synthons
Chao Chen, Ru-Xin Liu, Feng Xiong, Zi-Hao Li, Jun‐Chen Kang, Tong‐Mei Ding, Shu‐Yu Zhang
Abstract
radical cyclization. This reaction features good functional group tolerance, and deuterium and fluorine atoms could be introduced facilely from Freon-type methanes. Further transformation of halogenated oxindoles enabled the synthesis of many (labeled) bioactive drug molecules and skeletons, such as deuterated (±)-physostigmine, deuterated (±)-esermethole and deuterated (±)-lansai B.
Topics & Concepts
SynthonElectrochemistryChemistryFreonCombinatorial chemistryOrganic chemistryPhysical chemistryElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions