Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse
Grażyna Lietzau, Thomas Nyström, Zhida Wang, Vladimer Darsalia, Cesare Patrone
Abstract
= 0.049, respectively), and olfactory memory. We observed no changes in the investigated cellular mechanisms. We show that the early deterioration of olfactory parameters related to learning and memory is associated with a high content of sugar in the diet rather than with hyperglycemia or weight gain. This finding could be exploited for understanding, and potentially preventing, cognitive decline/dementia in people with T2D. The mechanisms behind this finding remain to be elucidated.
Topics & Concepts
OdorOlfactory memoryOlfactionOlfactory systemEndocrinologyInternal medicineType 2 diabetesNeurogenesisNeuroscienceBiologyPsychologyOlfactory bulbMedicineDiabetes mellitusCentral nervous systemOlfactory and Sensory Function StudiesBiochemical Analysis and Sensing TechniquesAdvanced Chemical Sensor Technologies