Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (<i>NIS</i>) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells
Mariella Tutter, Christina Schug, Kathrin A. Schmohl, Sarah Urnauer, Nathalie Schwenk, M. Petrini, Wouter J.M. Lokerse, Christian Zach, Sibylle Ziegler, Peter Bartenstein, Wolfgang Weber, Ernst Wagner, Lars H. Lindner, Peter J. Nelson, Christine Spitzweg
Abstract
gene radiotherapy with efficient tumor-selective and temperature-dependent accumulation of radioiodine in heat-treated tumors.
Topics & Concepts
Sodium-iodide symporterSymporterMesenchymal stem cellCancer researchIn vivoHyperthermiaChemistryBiodistributionMolecular biologyBiologyIn vitroPathologyMedicineGeneInternal medicineTransporterBiochemistryBiotechnologyCancer, Hypoxia, and MetabolismRadiation Therapy and DosimetryAdvanced Radiotherapy Techniques