FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC
Xilang Chen, Jie Chen, Weibo Feng, Wenjie Huang, Guodong Wang, Mengyu Sun, Xiangyuan Luo, Yijun Wang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Abstract
We demonstrated the essentiality of ELF4 in the metastatic process of CRC, and targeting the ELF4-relevant positive feedback circuit might represent a novel therapeutic strategy.
Topics & Concepts
Cancer researchFibroblast growth factor receptor 4MetastasisColorectal cancerOncogeneBiologyCancerFGF19Fibroblast growth factor receptorFibroblast growth factorReceptorCell cycleGeneticsFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation