Pathophysiological Roles of the cGAS-STING Inflammatory Pathway
Hiroshi Maekawa, Margaret E. Fain, Koichiro Wasano
Abstract
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) inflammatory pathway is a component of the innate immune system that recognizes cytosolic nucleic acids. The pathway has been implicated in several processes including aging, autoinflammatory conditions, cancer, and metabolic diseases. The cGAS-STING pathway represents a promising therapeutic target in a variety of chronic inflammatory diseases.
Topics & Concepts
StingStimulator of interferon genesInnate immune systemInflammationBiologySignal transductionImmune systemNucleic acidInterferonImmunologyCell biologyGeneticsEngineeringAerospace engineeringinterferon and immune responsesInflammasome and immune disordersCytokine Signaling Pathways and Interactions