Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress
Alyssa Margolis, Lin Liu, Steffen Porwollik, James Karl A. Till, Weiping Chu, Michael McClelland, Andrés Vázquez‐Torres
Abstract
Salmonella invades host cells and replicates inside acidified, remodeled vacuoles that are exposed to reactive oxygen species (ROS) generated by the innate immune response. Oxidative products of the phagocyte NADPH oxidase mediate antimicrobial activity, in part, by collapsing the ΔpH of intracellular Salmonella .
Topics & Concepts
BiologySalmonellaVirulenceMicrobiologyPhagocyteArginineOxidative stressMutantIntracellularBiochemistryReactive oxygen speciesNADPH oxidaseBacteriaAmino acidPhagocytosisGeneGeneticsSalmonella and Campylobacter epidemiologyVibrio bacteria research studiesEscherichia coli research studies