Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2
Akira Sato, Yoko Ogino, Sei-ichi Tanuma, Fumiaki Uchiumi
Abstract
RNA-RNA interaction assay, we observed hsa-miR-15b-5p interacting with the RNA component of viral RdRp. Our findings provide evidence that hsa-miR15b-5p may suppresses viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp.
Topics & Concepts
RNARNA-dependent RNA polymeraseRNA polymeraseCoronavirusBiologyVirologymicroRNANon-coding RNARNA polymerase ITranscription (linguistics)Molecular biologyCoronavirus disease 2019 (COVID-19)GeneGeneticsMedicineInfectious disease (medical specialty)DiseasePhilosophyLinguisticsPathologyMicroRNA in disease regulationSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiology