An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Xiangyu Liu, Jonas Kaindl, Magdalena Korczynska, Anne Stößel, Daniela G. Dengler, Markus Stanek, Harald Hübner, Mary J. Clark, Jake Mahoney, Rachel A. Matt, Xinyu Xu, Kunio Hirata, Brian K. Shoichet, Roger K. Sunahara, Brian K. Kobilka, Peter Gmeiner
Topics & Concepts
Allosteric regulationAllosteric modulatorChemistryAllosteric enzymeReceptorBiophysicsG protein-coupled receptorMolecular switchBinding siteStereochemistryBiochemistryBiologyMoleculeOrganic chemistryReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchCircadian rhythm and melatonin