Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity
Jie Tang, Yang Yang, Jingjing Qu, Wenhuang Ban, Hao Song, Zhengying Gu, Yannan Yang, Larry Cai, Shevanuja Theivendran, Yue Wang, Min Zhang, Chengzhong Yu
Abstract
Al-DMSN induced enhanced cellular immunity mediated by natural killer (NK) cells, cytotoxic T cells, and memory T cells as well as humoral immune response. Our results provide a new principle for the design of next-generation nanoadjuvants for vaccine applications.
Topics & Concepts
PyroptosisInnate immune systemAluminosilicateChemistryAcquired immune systemMesoporous materialMesoporous silicaCell biologyNanotechnologyInflammasomeMaterials scienceBiologyBiochemistryImmune systemImmunologyCatalysisReceptorInflammasome and immune disordersImmune Response and InflammationImmunotherapy and Immune Responses