Efficacy of molecular and nano-therapies on brain tumor models in microfluidic devices
Ana M. Martins, Alexandra Brito, Maria Grazia Barbato, Alessia Felici, Rui L. Reis, Ricardo A. Pires, Iva Pashkuleva, Paolo Decuzzi
Abstract
values). In the double-channel device, the cytotoxicity of free DTXL and DTXL-SPN is comparable, but significantly lowered as compared to the single-channel configuration. Finally, the administration of 500 μM Fmoc-Glc6P in the double-channel microfluidic device shows a 50 % U87-MG cell survival after only 24 h, and no deleterious effect on human astrocytes over 72 h. Concluding, the proposed microfluidic chips can be used to reproduce the 3D complex spatial arrangement of solid tumors and to assess the anti-cancer efficacy of therapeutic compounds administrated in situ or systemically.
Topics & Concepts
SpheroidMicrofluidicsDocetaxelBrain cancerChemistryCancer cellIn vitroMatrigelBiomedical engineeringCancerNanotechnologyCancer researchBiophysicsPharmacologyMaterials scienceMedicineBiologyBiochemistryInternal medicine3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationCancer Cells and Metastasis