Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Katsuhiko Ono, Yukio Fujiwara, Sunao Iyoda, Fan‐Yan Wei, Kazuaki Monde, Kazuko Seto, Makoto Ohnishi, Hiroyuki Oshiumi, Takaaki Akaike, Tomohiro Sawa
Abstract
proliferation and worsened symptoms such as intestinal hyperplasia and diarrhea. These findings highlight the inhibitory effect of SubAB on the NLRP3 inflammasome via ER stress, which may be associated with STEC survival and infectious disease pathogenicity in hosts.
Topics & Concepts
InflammasomeCitrobacter rodentiumMicrobiologyEnteropathogenic Escherichia coliEndoplasmic reticulumUnfolded protein responseEscherichia coliCaspase 1BiologySecretionLipopolysaccharideInflammationImmunologyCell biologyPathogenGeneBiochemistryEscherichia coli research studiesInflammasome and immune disordersVibrio bacteria research studies