Fentanyl vapor self-administration model in mice to study opioid addiction
Khaled Moussawi, Maria M Ortiz, Stephanie C. Gantz, Brendan J. Tunstall, Renata C.N. Marchette, Antonello Bonci, George F. Koob, Leandro F. Vendruscolo
Abstract
receptor-dependent currents during protracted abstinence from fentanyl vapor self-administration. This mouse model of fentanyl self-administration recapitulates key features of opioid addiction, overcomes limitations of the intravenous model, and allows investigation of the neurobiology of opioid addiction in unprecedented ways.
Topics & Concepts
FentanylOpioidAddictionSelf-administrationMedicineAdministration (probate law)Opioid addictionAnesthesiaPharmacologyPsychiatryInternal medicineReceptorPolitical scienceLawNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling