Regulation of the water channel aquaporin-2 by cullin E3 ubiquitin ligases
Sathish K. Murali, James A. McCormick, Robert A. Fenton
Abstract
Aquaporin 2 (AQP2) is essential for body water homeostasis and is regulated by the antidiuretic hormone vasopressin. The posttranslational modification ubiquitylation is a key regulator of AQP2 abundance and plasma membrane localization. Here we demonstrate that cullin-RING E3 ligases play a vital role in mediating some of the effects of vasopressin to increase AQP2 abundance and plasma membrane accumulation. The results suggest that manipulating cullin activity could be a novel strategy to alter kidney water handling.
Topics & Concepts
CullinUbiquitinAquaporinCell biologyWater channelChannel (broadcasting)ChemistryUbiquitin ligaseBiologyBiochemistryComputer scienceComputer networkGeneEngineeringMechanical engineeringInletIon Transport and Channel RegulationPancreatic function and diabetesDiet, Metabolism, and Disease