Highly efficient construction of 2,3-disubstituted indoline derivatives by [4 + 1] annulation of sulfur ylides and <i>o</i>-sulfonamido aldimines
Mengjiao Xu, Mengwei You, Su Yang, Boxue Ruan Lu, Ling Liu, Xin Lv, Shoulei Wang, Hui Mao, Liejin Zhou
Abstract
A highly efficient [4 + 1] annulation of sulfur ylide salts and o -sulfonamido aldimines for construction of valuable 2,3-disubstituted indolines is reported. It is worth noting that indoles could also be synthesized by this cascade reaction.
Topics & Concepts
AldimineAnnulationChemistrySulfurIndolineYlideOrganic chemistryCascadeMedicinal chemistryCatalysisChromatographyCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions