Design, synthesis and antimicrobial assessments of aminoacetylenic-piperazine nitroimidazole hybrid compounds
Anas J. Rasras, Raed A. Al‐Qawasmeh, Mohamed El‐Naggar, Ihsan A. Shehadi, Mahmoud M. Elaasser, Yaseen A. Al‐Soud
Abstract
Abstract A new series of aminoacetylenic nitroimidazole piperazine hybrid compounds were prepared via three-component reaction. Mannich-type reaction was utilized to couple the nitroimidazole containing propargylic moiety with secondary amines and formaldehyde in the presence of Cu (I) catalyst. The newly synthesized molecules 10a–10w , were characterized an ambiguously through NMR and mass spectrometry. The prepared compounds were assessed in vitro for their antibacterial activity against selected gram-positive and gram-negative bacteria. All of the compounds had shown insignificant activities toward gram-negative bacteria. While compounds 10m , 10q , 10s and 10t had shown moderate activities against the gram–positive bacteria Staphylococcus aureus , Bacillus subtilis and against fungi Escherichia coli and Proteus vulgaris .