Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity
Rejane Gonçalves Diniz Khodyuk, Ruoli Bai, Ernest Hamel, Estela Mariana Guimarães Lourenço, Euzébio Guimarães Barbosa, Adilson Beatriz, Edson dos Anjos dos Santos, Dênis Pires de Lima
Topics & Concepts
ChemistryCombretastatinTubulinStereochemistryActive siteCytotoxicityColchicineResidue (chemistry)IC50Disulfide bondIn vitroMicrotubuleBiochemistryEnzymeInternal medicineMedicineCell biologyBiologySynthesis and biological activityFungal Plant Pathogen ControlQuinazolinone synthesis and applications