Bioinspired Theranostic Coordination Polymer Nanoparticles for Intranasal Dopamine Replacement in Parkinson’s Disease
Javier García‐Pardo, Fernando Novio, Fabiana Nador, Ivana Cavaliere, Salvio Suárez–García, Silvia Lope‐Piedrafita, Ana Paula Candiota, Jordi Romero‐Giménez, Beatriz Rodríguez-Galván, Jordi Bové, Miquel Vila, Júlia Lorenzo, Daniel Ruiz‐Molina
Abstract
showed a rapid distribution within the brain of healthy rats, leading to an increase in striatal DA levels. More importantly, after 4 days of nasal administrations with DA-NCPs equivalent to 200 μg of the free drug per day, the number and duration of apomorphine-induced rotations was significantly lower from that in either vehicle or DA-treated rats performed for comparison purposes. Overall, this study demonstrates the advantages of using nanostructured DA for DA-replacement therapy.
Topics & Concepts
DopamineDopaminergicNeuromelaninBiodistributionPharmacologyNasal administrationParkinson's diseaseIn vivoChemistryBioavailabilityBiophysicsNanoparticleIn vitroNanotechnologyMedicineMaterials scienceSubstantia nigraBiochemistryDiseaseBiologyInternal medicineBiotechnologyParkinson's Disease Mechanisms and TreatmentsConducting polymers and applicationsDendrimers and Hyperbranched Polymers