Fecal Streptococcus Alteration Is Associated with Gastric Cancer Occurrence and Liver Metastasis
Dandan Yu, Jinru Yang, Min Jin, Bin Zhou, Linli Shi, Lei Zhao, Jieying Zhang, Zhenyu Lin, Jinghua Ren, Li Liu, Tao� Zhang, Hongli Liu
Abstract
The gut microbiome plays an indispensable role in the occurrence and progression of various diseases. However, its ability to predict gastric cancer (GC) and liver metastasis (GCLM) has not been fully identified. We retrospectively analyzed 49 untreated GC patients and 49 matched healthy people between 4 July 2020 and 9 March 2021. By extracting DNA from their fecal samples and sequencing the 16S rRNA gene, we found that Streptococcus alteration was strongly associated with GC occurrence and liver metastasis, which might be a potential biomarker in predicting GC and GCLM, and the results of this study are helpful in providing ideas for the early diagnosis and treatment of GC.