Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K
Chuanping Yu, Xinyuan Sun, Yan Wang, Shichao Du, Liang Shu, Qilei Sun, Fumin Xue
Abstract
model. By comparing the average ARD % values of the four models, it is found that the modified Apelblat model (ARD % = 1.26) provides better correlation. Hansen solubility parameters and apparent thermodynamic parameters were calculated to analyze the solubility behavior, indicating that the dissolution process is endothermic and entropically favorable.
Topics & Concepts
SolubilityGravimetric analysisDissolutionChemistryAcetonitrileNuclear chemistryAnalytical Chemistry (journal)Physical chemistryChromatographyOrganic chemistryCrystallization and Solubility StudiesAnalytical Chemistry and ChromatographyChemical and Physical Properties in Aqueous Solutions