Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway
Ningbo Cai, Bingtian Xu, Xing Li, Yunyun Qin, Mengfan Li, Kechun Chen, Jiangping Xu, Haitao Wang
Topics & Concepts
PharmacologyIschemiaBlood–brain barrierEndothelial dysfunctionMedicineNeuroprotectionTight junctionHES1Adherens junctionReperfusion injuryChemistryInternal medicineCell biologyBiologyNotch signaling pathwayCentral nervous systemBiochemistryCellReceptorCadherinNeurological Disease Mechanisms and TreatmentsPhosphodiesterase function and regulationNeuroinflammation and Neurodegeneration Mechanisms