Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture
Hyunsoo Jang, Seo Hyun Kim, Youmin Koh, Ki‐Jun Yoon
Abstract
context of the human fetal brain and achieve mature neural circuitry with an intact cytoarchitecture. In this review, we explore the major challenges facing the current brain organoid systems, potential technical breakthroughs to advance brain organoid techniques up to levels similar to an in vivo human developing brain, and the future prospects of this technology.
Topics & Concepts
CytoarchitectureOrganoidNeuroscienceContext (archaeology)Human brainNeurogenesisMammalian brainBiologyComputer sciencePaleontologyPluripotent Stem Cells ResearchNeuroscience and Neural EngineeringNeurogenesis and neuroplasticity mechanisms