Facile synthesis of isoquinolines and isoquinoline<i>N</i>-oxides<i>via</i>a copper-catalyzed intramolecular cyclization in water
Lujun Zhang, Wenfang Xiong, Biao Yao, Haitao Liu, Meng Li, Yu Qin, Yujian Yu, Xu Li, Meng Chen, Wanqing Wu, Jianxiao Li, Jin‐Liang Wang, Huanfeng Jiang
Abstract
-oxides, respectively, in moderate to high yields with good functional group tolerance and high atom economy. Moreover, the practicality of this method was further demonstrated by the total synthesis of moxaverine in five steps.
Topics & Concepts
IsoquinolineChemistryIntramolecular forceCatalysisOximeFunctional groupSolventCopperCombinatorial chemistryMedicinal chemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation