Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process
Wan Lei, Yongjun Liu, Yewen Fang, Yan Li, Chan Du, Jianghua Fang
Abstract
the reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.
Topics & Concepts
ChemistryPhotoredox catalysisPolarRadicalCrossoverCyclopropanationModular designCombinatorial chemistryPhotochemistryCatalysisPhotocatalysisOrganic chemistryComputer scienceOperating systemPhysicsAstronomyArtificial intelligenceCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions