EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Abstract
Our studies identify a novel anti-EGFR therapeutic strategy to inhibit cCSC aggregation and therefore abolish cCSC cluster-mediated metastasis of TNBC.
Topics & Concepts
CD44Cancer researchMetastasisCancer stem cellCancerLung cancerMetastasis suppressorMedicineBreast cancerTriple-negative breast cancerclone (Java method)CellBiologyOncologyInternal medicineDNAGeneticsCancer Cells and MetastasisCancer Genomics and DiagnosticsCancer, Hypoxia, and Metabolism