Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment
Yiling Peng, Li Li, Jingyue Shang, Haili Zhu, Jinlin Liao, Xue Hong, Fan Fan Hou, Haiyan Fu, Youhua Liu
Abstract
: Our findings uncover a novel mechanism by which macrophages contribute to kidney fibrosis via assembling a Vtn-enriched extracellular niche and suggest that disrupting fibrogenic microenvironment could be a therapeutic strategy for fibrotic CKD.
Topics & Concepts
FibrosisKidneyFibroblastKidney diseaseCancer researchExtracellular matrixVitronectinCell biologyChemistryBiologyMedicineEndocrinologyInternal medicineFibronectinIn vitroBiochemistryChronic Kidney Disease and DiabetesTissue Engineering and Regenerative MedicineAcute Kidney Injury Research