Regulation of insulin secretion by the post-translational modifications
Chunhua Yang, Mengna Wei, Yanpu Zhao, Zhanyi Yang, Mengyao Song, Jia Mi, Xiaoyong Yang, Geng Tian
Abstract
Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in β cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in β cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.
Topics & Concepts
SecretionInsulinDiabetes mellitusPosttranslational modificationCell biologyFunction (biology)BiologySignal transductionEndocrinologyBiochemistryEnzymePancreatic function and diabetesMetabolism, Diabetes, and CancerAutophagy in Disease and Therapy