CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy
Qie Guo, Xiao Li, Mengna Cui, Jialin Sun, Hongyan Ji, Beibei Ni, Mei-Xing Yan
2020Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics35 citationsDOIOpen Access PDF
Abstract
Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence.
Topics & Concepts
Multiple drug resistanceCancerCancer chemotherapyChemotherapyMedicineCancer cellCancer treatmentDrug resistanceCancer researchInternal medicineBiologyMicrobiologyCancer Cells and MetastasisCancer therapeutics and mechanismsNanoparticle-Based Drug Delivery