PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer
Yujia Song, Xiaohui Wang, Yuqi Sun, Nianhua Yu, Yajie Tian, Jinli Han, Xian‐Jun Qu, Xinfeng Yu
Abstract
. Collectively, these results provide a novel insight into the molecular chaperone activity of PRDX1 in promoting CRC progression through suppression of CUL3-mediated NRF2 degradation, suggesting PRDX1 Cys83 is a potential drug target in inhibiting CRC.
Topics & Concepts
Colorectal cancerCullinChaperone (clinical)Cancer researchBiologyChemistryCell biologyCancerBiochemistryMedicineGeneticsGenePathologyUbiquitinUbiquitin ligaseFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research