Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway
Kangtao Jin, Lin Zheng, Lin Ye, Ziang Xie, Jiawei Gao, Chao Lou, Wenzheng Pan, Bin Pan, Shijie Liu, Zhenzhong Chen, Dengwei He
Topics & Concepts
OsteoclastBone resorptionMacrophage migration inhibitory factorOsteoblastRANKLChemistryDownregulation and upregulationBone remodelingCell biologyOsteolysisSignal transductionEndocrinologyNF-κBCancer researchInternal medicineBiologyCytokineIn vitroActivator (genetics)ReceptorMedicineBiochemistryGeneSurgeryMacrophage Migration Inhibitory FactorBone Metabolism and DiseasesNuclear Receptors and Signaling