The Role of the Gut Microbiome in Resisting Norovirus Infection as Revealed by a Human Challenge Study
Nastassia Patin, Ángela Peña, Janet K. Hatt, Christine L. Moe, Amy Kirby, Konstantinos T. Konstantinidis
Abstract
The role of the human gut microbiome in determining whether an individual infected with norovirus will be symptomatic is poorly understood. This study provides important data on microbes that distinguish asymptomatic from symptomatic microbiomes and links these features to infection responses in a human challenge study. The results have implications for understanding resistance to and treatment of norovirus infections.
Topics & Concepts
NorovirusMicrobiomeGut microbiomeVirologyBiologyMurine norovirusComputational biologyMicrobiologyMedicineImmunologyBioinformaticsVirusViral gastroenteritis research and epidemiologyClostridium difficile and Clostridium perfringens researchChild Nutrition and Feeding Issues