Role of the p38MAPK signaling pathway in hippocampal neuron autophagy in rats with chronic intermittent hypoxia
Yuxin He, Zhili Liu, Yinpei Huang, Bing Li
Abstract
The pathophysiological processes related to autophagy obstructive sleep apnea-hypopnea syndrome (OSAHS) are unclear. This study clarified that the inhibition of the p38MAPK signaling pathway could further activate autophagy in hippocampal nerve cells, thus reducing nerve cell injury.
Topics & Concepts
Hippocampal formationMorris water navigation taskWestern blotEndocrinologyNeuronAutophagyInternal medicinep38 mitogen-activated protein kinasesHippocampusH&E stainHypoxia (environmental)Water mazeChemistryApoptosisSignal transductionBiologyMAPK/ERK pathwayImmunohistochemistryMedicineCell biologyNeuroscienceBiochemistryGeneOxygenOrganic chemistryAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon MonoxideNeuroinflammation and Neurodegeneration Mechanisms