Facile Electrochemically Reduced Graphene Oxide‐Multi‐walled Carbon Nanotube Nanocomposite as Sensitive Probe for <i>in‐vitro</i> Determination of Nitrofurantoin in Biological Fluids
Shekher Kummari, V. Sunil Kumar, K. Vengatajalabathy Gobi
Abstract
Abstract In this work, electrochemically reduced graphene oxide ‐ carbon nanotube (multi‐walled) nanocomposite modified glassy carbon electrode (ErGO‐CNT/GCE) has been investigated for direct electrochemical determination of nitrofurantoin (NFT), which is the prime drug used in the treatment of urinary tract infection. Surface of ErGO‐CNT/GCE has shown leafy flake‐like layers on the nanowire bed of CNTs, promising porous surface structure with enhanced surface area. ErGO‐CNT/GCE showed high peak current along with low overpotential in sensing NFT. In differential pulse voltammetry studies, the low detection limit is 20 nM. Steady state current ‐ time analyses carried out in buffer and serum samples resulted a low‐detection‐limit of 1.87 nM with the analysis time of mere 5 s. Practical application of the fabricated sensor for NFT determination in serum samples has been demonstrated.