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Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea

Gabriel Tao, Fatima Dagher, Li Li, Rashim Singh, Ming Hu, Romi Ghose

2022Food and Chemical Toxicology13 citationsDOI

Topics & Concepts

IrinotecanDiarrheaPharmacologyToxicityMetaboliteTLR2Active metaboliteLoperamideTLR4ProdrugMedicineChemistryInternal medicineInflammationColorectal cancerCancerCancer therapeutics and mechanismsNeutropenia and Cancer InfectionsLung Cancer Research Studies
Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea | Litcius