Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection
Morgane Rolland, Peter B. Gilbert
Abstract
Sieve analyses will compare Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) sequences from breakthrough infections in vaccine recipients to the sequences found in placebo recipients to understand if vaccination fails to protect against specific genetic variants, characterize the potential impact of vaccines on SARS-CoV-2 evolution, and help design nextgeneration vaccines.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)VirologyVaccination2019-20 coronavirus outbreakSieve (category theory)CoronavirusMedicineImmunologyBiologyInternal medicineOutbreakMathematicsDiseaseCombinatoricsInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesAnimal Virus Infections Studies