Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
Didier Dewailly, Anne‐Laure Barbotin, Agathe Dumont, Sophie Catteau-Jonard, Geoffroy Robin
Abstract
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.
Topics & Concepts
Anti-Müllerian hormonePolycystic ovaryFolliculogenesisPathogenesisMedicineInternal medicineEndocrinologyHormonePathophysiologyOvaryBioinformaticsBiologyInsulin resistanceDiabetes mellitusEmbryogenesisCell biologyEmbryoOvarian function and disordersReproductive Biology and FertilityOvarian cancer diagnosis and treatment