Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity
Prasida Holla, Brian Dizon, Abhijit A. Ambegaonkar, Noga Rogel, Ella Goldschmidt, Arun K. Boddapati, Haewon Sohn, Dan E. Sturdevant, James W. Austin, Lela Kardava, Yuesheng Li, Poching Liu, Susan Moir, Susan K. Pierce, Asaf Madi
Abstract
ABCs acquired a high antigen affinity threshold for activation, suggesting that ABCs may limit autoimmune responses to low-affinity self-antigens in chronic malaria.
Topics & Concepts
AutoimmunityMalariaFunction (biology)Human immunodeficiency virus (HIV)ImmunologyBiologyVirologyComputational biologyGeneticsImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses